Actin polymerization: Where the WASP stings

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Actin polymerization: Where the WASP stings

How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Rac, have now been shown to link via proteins of the WASP family to the Arp2/3 complex, which nucleates actin polymerization.

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Protrusion of lamellipodia and filopodia from the cell surface requires that actin polymerize locally. Actin polymerization is initiated by numerous agonists, including growth factors, chemoattractants, extracellular matrix, and phagocytic particles. The signaling pathways from the corresponding receptors converge on Rho family GTPases, especially Rac and Cdc42, which induce actin polymerizatio...

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Wasp stings with multisystem dysfunction.

The insect order of Hymenoptera includes bees, hornets, wasps and fire-ants. Their stings are not usually life threatening, causing mainly local reactions and rarely anaphylaxis. This is a report of an 18 month old child who survived after an unusually severe envenomation, resulting in encephalopathy, hypertension, coagulopathy, intra-vascular hemolysis, hepatic and renal failure, following mul...

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Wasp bite induced ATN from direct venom toxicity is very rare. We report two such cases. The first case was a 14 years old boy admitted with oliguria following multiple wasp stings. He had grossly deranged renal function requiring hemodialysis support. The other patient was a 24 years old man admitted with similar history and also required hemodialysis support. Renal biopsy in both cases was co...

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ژورنال

عنوان ژورنال: Current Biology

سال: 1999

ISSN: 0960-9822

DOI: 10.1016/s0960-9822(99)80102-x